In my early undergraduate days I studied tropane alkaloids for some time. These amazing compounds are very important in modern day pharmacy. Their history with mankind is also ancient and eventful. I stopped studying them as my final year was getting closer. So I decided to organize stuffs and publish them online.
Tropane derivatives are among the economically most important pharmaceuticals (Rates 2001; Raskin 2002). Various pharmaceutical industries are manufacturing over 20 active pharmaceutical ingredients (APIs) containing the tropane moiety in their structures; they are applied as mydriatics, antiemetics, antispasmodics, anesthetics, and bronchodilators (Grynkiewicz and Gadzikowska, 2008). The first tropane derived API was homatropine, it was introduced by E. Merck Company as a new mydriatic in 1883.